The Bishop Portier House is a historic home in Mobile, Alabama. Built in 1834, it initially served as the residence of Bishop Michael Portier, the very first Roman Catholic Bishop of the city of Mobile. The bishop lived here from its completion until his death in 1859. Four other bishops after Portier lived here as well.

Aside from its connection to Bishop Portier, the Bishop Portier House is also best noted for its architecture. Built as a Creole cottage with neoclassical details, the house is actually one of Mobile?s best examples of the said architecture. It was designed by Portier?s nephew, Claude Beroujon, who was also a seminarian architect.

The Bishop Portier House was recently restored in 2007 by the archdiocese. It is now placed on the National Register of Historic Places.