The Curtis House is a historic home in Demopolis, Alabama. It was built in 1840 by Samuel Curtis, thus the name. Curtis was a Revolutionary War veteran. He was born in Maryland in 1751 and moved to Alabama in the 1800s. It is in this house where he passed away in 1846.

The Curtis House is mostly historically significant for its architecture. It was initially built in the Federal style of architecture, but later changes added Greek Revival features in o it, the most notable of which is the Greek Revival influenced portico.

Also known as the Howze-Culpepper House, the Curtis House was added to the National Register of Historic Places on April 1977. It was also included on the publication, The heritage of Marengo County, Alabama.