The John Hand Building is a historic high rise structure in Birmingham, Alabama. It was built in 1912 and once served as the tallest building in the city, until it was surpassed by the City Federal Condos in height a year later.

The John Hand Building is a 10-story structure. It was used for various purposes in the past, letting it gain various alternative names like the First National Bank, American Trust & Savings Bank Building, and the American Traders National Bank.

The John Hand Building is currently a mix-use structure. Its lower floors are used for commercial purposes, while its upper 12 floors are residential units. It is also a part of the Heaviest Corner on Earth, a historic district in Birmingham. The building alone is also a part of the National Register of Historic Places.