The Murphy African-American Museum is a period museum in Tuscaloosa, Alabama. It is focused on the lifestyle of the affluent African-Americans during the early 1900s.

Housed in the historic 1920s Murphy-Collins House, the Murphy African-American Museum?s location was once the home of the first licensed black mortician, Will J. Murphy. The house was built as a private residence using the salvaged materials from the old state capitol building that burned in 1923.

On display in the Murphy African-American Museum are period furniture, irons, kettles, and artifacts like combs and curlers, used by early 1900s African Americans. They also have Murphy family memorabilia exhibited, as well as local history, African art and artifacts.

The Murphy African-American Museum is open every Tuesdays through Fridays from 10 am to 4 pm.