The Raphael Semmes House is a historic residence in Mobile, Alabama. It is also known as the Horta-Semmes House, after the two most prominent and significant owners of the property.

The Raphael Semmes House is best noted for its association with Admiral Raphael Semmes. Semmes served as a captain for the Confederate sloop-of-war CSS Alabama. The house was originally built by Peter Horta in 1858, and by 1871, it was gifted to Semmes by the citizens of Mobile. The property became his home until his death in 1877.

The Raphael Semmes House was later acquired by Mr. Joseph Linyer Bedsole, a prominent local philanthropist. He restored the house and then donated it to the First Baptist Church of Mobile that is located next door. He gave the property as a gift in memory of his son, Lt. Joseph Linyer Bedsole Jr., who died while in service during the Second World War in Germany.