The Spring Hill College Quadrangle is a historic site where a series of structures are deemed historically significant. The complex is located inside the campus of Spring Hill College in Mobile, Alabama.

The Spring Hill College Quadrangle is composed of a couple of buildings competed in the 1800s. It features the school’s old main building, a Neo-Renaissance style structure, which was constructed in 1869 as a replacement to the 1831 structure that burned down. There is also the St. Joseph’s Chapel, built around 1910. The area of the site is enclosed by a pretty arched arcade that is topped with crenellation.

The Spring Hill College Quadrangle was made a part of the National Register of Historic Places in August 1973.