The Trail of Tears Remembrance Motorcycle Ride is an annual event in the South. It stars in Chattanooga Tennessee and concludes at the McFarland Park in Florence, Alabama where programs and other events also take place.

The Trail of Tears Remembrance Motorcycle Ride commemorates ?one of the darkest episodes in relations between the US and the Native Americans?, which is the Trail of Tears. This event followed the enactment of the Indian Removal Act of 1830 which forced many Native Americans to flee their lands and relocate to Oklahoma. It aims to promote awareness about the said historic event.

Considered as the largest destination motorcycle ride in the world with at least a hundred thousand riders participating, the Trail of Tears Remembrance Motorcycle Ride is held yearly during the third Saturday of September.