The San Rafael State Natural Area is a state natural preservation intended to maintain and preserve the native grassland located in Patagonia, Arizona.

Unlike most other areas in the state of Arizona, the native grasslands area of the San Rafael State Natural Area has not suffered from a proliferation or invasion of foreign vegetation like shrubs and cactus. This area features rolling hills, oak, and cottonwood trees, and native grasses. The valley is also the headwaters of the Santa Cruz River. Other than native vegetation, several animal species also call the natural area home. This includes mule deer, javalina, antelope, bobcats, cougars, cayote, and several species of prairie birds.

Currently, the park is not open for public use and there are no plans to open the park to the public.