The Henry B. Plant Museum is a museum in Tampa, Florida. It celebrates and preserves the story of the historic Tampa Bay Hotel and its creator, Henry B. Plant.

Henry B. Plant is one of the bold builders that helped shape Florida into a bustling state that it is today from the forests and swamps that it has always been up until the last century. He built the 501-room Tampa Bay Hotel in 1891, which had every luxury possible and ushered in a great deal of tourism in the area.

Today, the Tampa Bay Hotel may be already used largely as a part of the University of Tampa, but some areas are still dedicated as the Henry B. Plant Museum. It features displays about the glory days of the hotel.