The Mel Fisher Maritime Heritage Museum is a maritime museum in Key West, Florida. It is best known for being the home of the early 1980s shipwreck artifacts hauled by Mel Fisher and his crew.

The Mel Fisher Maritime Heritage Museum started out after the shipwreck of the Spanish galleon called the Nuestra Senora de Atocha (which met its tragic fate in 1622) was found by a crew led by Mel Fisher, commonly distinguished as an ?American treasure hunter?. The haul was called the shipwreck find of the century. Aside from the Atocha, there are also other artifacts from other 17th century wrecks displayed on the site, include those from the Santa Margarita and the Henrietta Marie.

The Mel Fisher Maritime Heritage Museum is open all week long and all year long.