The Mote-Morris House is a historic house museum in Leesburg, Florida. It is best known for its association with Edward H. Mote, a former city mayor who served Leesburg for eight terms.

The Mote-Morris House was built in 1892 for the Mote family. It took $9000 to build and is generally a two-story dwelling with a four-story turret. In 1908, the property was sold to Bishop Henry Clay Morrison who used it as his retirement home. Ten years later, it was sold to the Morris family who took resided in the house for the next 70 years.

Today, the Mote-Morris House is owned by the City of Leesburg. It is opened for tours twice a month and is open for events rentals.