The Mound House is a historic site in Fort Myers, Florida. It features a house that is perched atop an Indian mound.

The Mound House is one rare venue due to many factors. For one, it is one of the few Calusa Indian village sites that are known to be situated on a barrier island in the southwest region of the state. The shell mounds are also remarkably well preserved, despite being inhabited by settlers in the early 1900s, which is the date that experts attribute the construction of the house.

The historic Mound House is also used as a museum and cultural center. It is open to the public on Mondays through Saturdays from 8:30 am to 4:30 pm.