The Safford House Museum is a historic house museum in Tarpon Springs, Florida. It is operated by the city of Tarpon Springs.

The Safford House Museum features the historic 1883 Safford House. The house was named after its original owners, the Safford family, headed by Anson P.K. Safford. The family moved to Tarpon Springs in the late 1800s and lived in the said house.

Today, the Safford House Museum is considered as a fine example of late 19th century Florida vernacular architecture. It is furnished and restored to its Victorian splendor through the funding of the State of Florida, local city government, and the Save America?s Treasures grant.

The Safford House Museum is open every Wednesdays and Fridays from 11 am to 3 pm.