The Sanford Museum is a local history museum in Sanford, Florida. It features a collection of displays and historic items that illustrate the history and development of the City of Sanford.

The Sanford Museum was initially built as a memorial to Henry Shelton Sanford, the founder of the city of Sanford. This is why some displays are about the life and times of the great man, who served the community as a diplomat, lawyer, and innovator in the citrus industry. The museum houses his personal library, as well as a collection of decorative arts from the 19th century.

The Sanford Museum primarily serves as a history repository for the city. There are also opportunities for researchers on their visits to the site, with its title collection.