Lots of wineries in the Carbondale/Anna/Alto Pass area, not much for breweries, which is crazy for a college town. I heard Murphysboro had something like a brewpub.
there is a craft brewery from murphysboro called big muddy brewing, they're pretty new and have only a few types. they sell it in local liquor stores and a few bars around the area like the cellar in carbondale (cool place) and 17th street bar n grill in murphysboro.
Whatever happened to the Copper Dragon? It was a brewpub over by Pinch Penny Pub, I think there were tring to make it more of a huge club but they used to have like 5-6 brews. I'm sure there out of business, but never heard for sure.