If you can drive around crater lake you would enjoy that, but it's not on the coast. Don't bother in the winter though.
The southern half of 101 has downright amazing scenery also.
Someone mentioned the Beachfront Inn in Brookings, I'd say go for it if you make it that far, because it is the best in town, but the beach it's on is bleh. Harris beach is better for a day out. My favorite is rainbow rock, it's always quite - hardly any locals even go there. It's just a 2 minute trail off the highway.
If you make it down this far, you've got to check out natural bridges, arch rock, and indian sands (especially on a big swell day) and rainbow rock. all on 101 and marked decently.
Oh, and Oregons tallest bridge, Thomas Creek Bridge.