Venice Cafe is awesome! Always very impressive to out of towners. Live bands and re-frickin'-dickulous decor. The WHOLE place has been mosaiced by the person who did the city museum... oh, THE CITY MUSEUM! There's one! At night on the weekends it's a bar too The Venice Cafe | Saint Louis, Missouri | 314.772.5994
+1 on City Museum! The Cathedral Basilica is one of the largest mosaic works of art in the world. Amazing to look at regardless of the religious aspect. The Saint Louis Zoo is not only free, but one of the best Zoos in the country.
As far as food- +1 on Pappy's & Crown Candy. Gotta add Blues City Deli, O'Connell's Pub (especially for fish & chips on Fridays) and Lemp Mansion.