Angel Mounds State Historic Site is situated along the Ohio River near the counties of Warrick and Vanderburgh in Evansville, Indiana. It was a thriving Mississippian Indian town around five hundred to seven hundred years ago. Angel Mounds was built between 1050 and 1400 A.D., and was occupied by more than a thousand inhabitants until it was abandoned around 1450 A.D. It was considered as the largest settlement in Indiana within that time. Also, it becomes the center of government, trade, and religion for little outpost communities.

At the time the Angel Mounds was abandoned, the site was vacant; there were no evidences shown why dwellers left the place. There are several speculations that may cause the desertion of town. These assumptions include depletion of local supply of wood for building and fire purposes, political turmoil, and scarcity of natural resources.

At present, Angel Mounds State Historic Site has been managed by various government agencies in Indiana. It was coined as one of the sixteen state museums and historic sites in the United States.