The Wickliffe Mounds State Historic Site is a state park and historic site in Wickliffe, Kentucky. It is a prehistoric archaeological site listed on the US National Register of Historic Places.

Originally a Mississippian culture Indian village, the Wickliffe Mounds State Historic Site dates back to the 1100 to 1350 AD. It served as a ceremonial and administrative center of what is evidenced as an important chiefdom in the culture. It is even believed to have had hundreds of residents at its peak.

Composed of two large platform mounds and about eight smaller mounds, the Wickliffe Mounds State Historic Site is also home to a museum where artifacts excavated at the site are on display. It is open year round from 9 am to 4:30 in the afternoon.