The Omni Detroit Hotel at River Place used to be the Parke-Davis Research Laboratory. It was completed in 1902 and served as the first ever structure specifically built for housing pharmacological research, it was declared as a National Historic Landmark in 1976.

The Omni Detroit Hotel at River Place can be found in a complex in Detroit, Michigan. The whole campus is composed of 26 still extant buildings. The structures were mostly designed by the Donaldson & Meier architectural firm in the Romanesque Revival.

When the complex was acquired by the Stroh family in 1979, they turned it to the Omni Detroit Hotel. They did some additions, which made the National Park Service to question the site?s historic integrity.
The Omni Detroit Hotel at River Place closed its doors in October 2010. Plans as to what will become of the building are still unclear today.