The McComb Historic Railroad Museum is a railroading museum in McComb, Mississippi. It traces the development of the community and the effects brought upon it by the railroad.

Housed in the McComb Amtrak station that was built in 1901 by the Illinois Central Railroad, the McComb Historic Railroad Museum features displays and memorabilia about the local railroading heritage. Older generations will remember the ?Voice of McComb? or the train whistle that was once used to measure days. Every time folks hear it, they would know that it is already 1 pm or 4 pm, always being on schedule.

The McComb Historic Railroad Museum is also currently the home of the #2542, a 200-ton steam locomotive and one of the two largest steam engines in the ICRR fleet, as well as the #5100 which is the only aluminum refrigerator car that was ever built.