The Mississippi Museum of Art is a community-supported institution that has existed for over 100 years and it has been on its former location since the 1970's. Their staffs are composed of seasoned professionals and responsible administrators whose experiences have spanned for as long as 30 years.

Starting with only a few hundred pieces, the permanent collection of the Museum now has about 3,800 artworks focusing on the mid-19th and 20th century American art. From paintings to sculptures, drawings, prints, and photographs, the Museum features notable artists like Albert Bierstadt, Robert Henri, Arthur B. Davies, George Inness, Thomas Sully, and J. A. M. Whistler.

The Mississippi Collection of the Museum also includes a wide selection of works by Mississippi artists like 19th-centur painter G. Ruger Donoho.