The Pleasant Reed House is an African American heritage museum in Biloxi, Mississippi. It is operated by the Ohr-O?Keefe Museum of Art.

Built around the 1880s and 1890s, the Pleasant Reed House was originally the home of the Reed family, constructed by its original owner, Pleasant Reed. Reed was a former slave on a Mississippi farm. He moved to Biloxi after the Civil War and worked as a carpenter and laborer. The site is a testament and even a memorial to all the common men and women who worked hard to define the American Dream.

The original Pleasant Reed House was destroyed by Hurricane Katrina, but thanks to the efforts of the community and specific groups, it was replicated. The reproduction of the original house opened to the public in September 29, 2008.