The Mark Twain State Park is a state park and recreation area in Stoutsville, Missouri. It is the third oldest state park in Missouri.

Created in the 1920s, the Mark Twain State Park was established through the efforts of the Mark Twain Memorial Park Association. It was founded in honor of the Missouri-born author-humorist Samuel Clemens, best known through his pen name, Mark Twain. It overlooks the 18,600-acre Mark Twain Lake and is filled with plants that are common in the southern Ozark Region, despite not being inside that locale.

Visitors of the Mark Twain State Park can enjoy fishing, boating, camping, swimming, hiking, and picnicking at the site. There are also some camper cabins available at the site as well as a playground for kids.