The Nathan Boone Homestead State Historic Site is a state park, historic site, and recreation area in Ash Grove, Missouri. It is best noted for its association with the Boone family.

The Boones are best known for their achievements as early settlers in what is now the United States of America. Daniel Boone made the name famous, and Nathan Boone was his youngest son. Nathan Boone also made quite a name for himself, being a noted hunter, surveyor, soldier, and businessman. The Nathan Boone Homestead State Historic Site was actually created in 1991 as a means to preserve his homestead.

The Nathan Boone Homestead State Historic Site aims to provide an authentic look at how early Americans and Missouri residents lived and spent their days.