Ghost Ranch is a 21,000-acre (85 km2) retreat and education center run by the Presbyterian Church (U.S.A.), located close to the village of Abiquiu in Rio Arriba County in north central New Mexico. The conference center and lodgings at Ghost Ranch are open to both members of the Presbyterian Church and the general public.

Ghost Ranch is the subject of many landscapes by the American painter Georgia O'Keeffe, who maintained a summer home there in 1934, then her permanent residence on the property from 1949 until her death. Her ashes are scattered at Ghost Ranch.

The last private owner of the Ghost Ranch was Arthur Newton Pack, who donated the ranch to the Presbyterian Church. Arthur Pack was also the publisher of Nature magazine, who opened the Ghost Ranch Lodge in Tucson, Arizona, and contributed to the creation of the Arizona-Sonora Desert Museum.

Ghost Ranch includes a famous palaeontological site preserving Triassic dinosaurs. Fossil bones were found here as early as 1885. In 1947 the palaeontologist Edwin H. Colbert documented the discovery of over a thousand well-preserved fossilized skeletons of a small Triassic dinosaur called Coelophysis in a quarry here.

Ghost Ranch is home to the Florence Hawley Ellis Museum of Anthropology and the Ruth Hall Museum of Paleontology.

Ghost Ranch is a year-round education and mission center of the Presbyterian Church for people of diverse faiths, racial, and cultural origins. The beautiful high desert landscape and programs are designed to give participants an experience of rest, re-creation, and renewal.

In summer 2001 Ghost Ranch began offering a new array of courses in outdoor adventure including low and high ropes, kayaking, horseback riding, and hiking.