The Santuario de Guadalupe is a historic church in Santa Fe, New Mexico. It is best known for being the oldest shrine to New Mexico?s patron saint, Our Lady of Guadalupe, in the entire United States.

Built around 1776 to 1795, the Santuario de Guadalupe is an excellent example of Spanish Colonial architecture. It is formally known as the Nuestra Senora de Guadalupe Church and is also home to an art and history museum featuring the collection of the Archdiocese of Santa Fe. Among the pieces on display are New Mexican santos or carved images of saints, Mexican baroque paintings, and Italian Renaissance paintings. It is also home to one of the works of a well renowned Mexican painter, Jose de Alzibar, dated 1783 and considered as one of the largest and finest oil paintings of the Spanish Southwest.