Cape Lookout National Seashore preserves a 56-mile (90-km) long section of the Southern Outer Banks, or Crystal Coast, of North Carolina, USA, running from Ocracoke Inlet on the northeast to Beaufort Inlet on the southeast. Three undeveloped barrier islands make up the seashore - North Core Banks, South Core Banks and Shackleford Banks. The seashore includes two historic villages on Core Banks, Shackleford's wild horses, and the Cape Lookout Lighthouse, which has a black-and-white diamond pattern. A visitors center for the seashore is located on Harkers Island.

The National Seashore was authorized on March 10, 1966. It was named a North Carolina Natural Heritage Area on May 23, 1986. The seashore was designated the Carolinian-South Atlantic Biosphere Reserve on June 16, 1986. Near noon on September 9, 2007, Tropical Storm Gabrielle made landfall at this exact point with winds of 60 mph (97 km/h). Damage was light but flooding and beach erosion affected this lookout.