The North Dakota Lewis & Clark Interpretive Center focuses on the Lewis & Clark Expedition, specifically the time at Fort Mandan in the winter of 1804-1805. The Center features displays artifacts and objects that visitors can try on such as the buffalo robe. Its collection and displays focus on Native American artifacts including a cradle board that is used in carrying babies, an authentic wood canoe tree that demonstrates the winter preparations in Fort Mandan during the Expedition.

The richness of Fort Mandan history is further depicted in the journey of Lewis and Clark as they left for the west, the establishment of Fort Clark in 1830, and many more.

The Museum also features the Bergquist Gallery, which is only one of the four galleries in the world housing a complete collection and rotating the prints of Karl Bodmer seasonally. These art pieces are watercolor and Maximilian?s written descriptions that are considered to be the most complete and reliable eyewitness account of the Upper Midwest Indian cultures. Another exhibit in the Center is the Sheldon Gallery, which focuses on the history of steamboats, frontier trade, and Native American culture.