The Oklahoma Frontier Drugstore Museum was established in 1992 that seeks to preserve historical artifacts, information, and collection pertaining to pharmacy and medical practices performed by professionals within Oklahoma State. The museum, located at the Historical District at Gaffney Building, Guthrie, was a fruition of the project spearheaded by pharmacist Ralph Enix, along with his colleagues. Presently, the museum is run by the Oklahoma Heritage Foundation, Inc. The son?s founder, Mark ekiss, became the manager and curator.

The museum became the home of several historical artifacts and archives on pharmacy and medicine that came into existence since the 19th and 20th centuries. There are also a few collectables of antiques, esoteric remedies, pharmaceuticals, cigar memorabilia as well as authentic drugstore memorabilia, which were donated by descendants of physicians. The most notable invention is the soda fountain made during the 19th Century.
The museum also provides access to documents of medicinal remedies, herbal treatments, and health advices written by late pharmacists and doctors.

The Museum is very memorable to visit because of its Apothecary Garden, located on the west side of the museum. Opened in 2006, the garden is a venue for research on herbs and plants for health relief. Also, it is currently the place for people to relax and rest while enjoying the beauty of the flower gardens. Benches were placed as a resting place for joggers and museum visitors. The Guthrie community is encouraged to volunteer and spare their time to plant medicinal herbs and plants for the future of the garden.

The Oklahoma Frontier Drugstore Museum welcomes guided tours and special events for groups through advance reservations by phone or email. Special rates and discounts are given for educational field trips and for larger groups. For normal operations, the museum is open from Tuesdays to Saturdays.