Originally known as the Museum of the Western Trails, the Oklahoma Route 66 Museum used to be under the authority of the Oklahoma Tourism department since it was built in 1968. It now dons a new name and has been operated by The Oklahoma Historical Society ever since it was transferred to them in 1991. Two years later, the museum was renovated and developed to showcase Route 66 and the history of transportation. In September 23, 1995, it was reopened with a grand celebration that featured live performances, car shows, rock and roll dance and various activities.

The tour of the museum starts with the ?The World?s Largest Curio Cabinet? where visitors can view a big collection of unique pieces gathered from the Route through the years. Throughout the tour, visitors are both educated and entertained with audio, video and physical displays depicting the history of transportation, road building, and other developments that happened along Route 66. The tour ends with a clip entitled ?The American Odyssey? in the museum?s drive-in theater. Guests are then led to the Curio gift shop where one can buy all sorts of souvenirs and unique stuff about Route 66 and the Oklahoma Route 66 Museum.