A structure built for the Reformed Christian church in Newport, Rhode Island, the Clarke Street Meeting House is a 1735 building listed on the National Register of Historic Places in 1971. It was originally constructed for the Second Congregational Church, a Calvinist congregation, to be used as a worship place. Ezra Stiles, the famous minister who became Yale University?s president later on, became a pastor of the church for more than twenty years.

The Clarke Street Meeting House, also known as the Central Baptist Church, and the Second Congregational Church Newport County at different times, was also used as barracks and hospital for the British troops during the American Revolutionary War.

Today, the Clarke Street Meeting House is owned by St. Joseph?s Church of Newport, who purchased the property in 1950.