Built in 1855, the Beaty-Little House is mostly treasured for being one of the last few remaining antebellum houses in the city of Conway. It is one of the surviving residential structures built before the Civil War, making it also one of the relatively older buildings in the locale. Aside from this, the house is also historically significant for its connection with John R. Beaty and Henry P. Little.

The Beaty-Little House was built for John Robinson Beaty by the shipbuilders Eaton brothers. The brothers moved to South Carolina from Maine to start building ships in the Waccamaw River. The property stayed in the family until 1904 when it was purchased by Henry Pyle Little, a building contractor from Tennessee who also did work in the city.