The Cayce Historical museum serves as a venue where residents and visitors can learn about the history of their city. It interprets the agricultural, social, and cultural heritage of the Cayce, Old Saxe Gotha, Granby, and West Columbia areas. It documents the history of the first European settlement in the South Carolina's Midlands in the early 1700s.

Visitors to the Museum will get to learn more about the area?s colonial trade and agricultural development. The Museum covers the development of transportation beginning from the 18th century up to the present time. Native American artifacts from thousands of years ago are displayed within the Museum as well.

The Cayce Historical Museum occupies a trading post replica built in 1765 in the Cayce area. It serves as the main building of the Museum complex. The British seized the actual trading post and used it as a fort during the American Revolution. The Cayce family purchased the building in 1817 and used it as their private residence for almost a century. One family member, Uncle ?Billy" Cayce, managed a general store in an area which was then named as Cayce Crossing. In 1914, the town was incorporated and named after the Cayce family.