The C.P. Quattlebaum Office is a historic building in Conway, South Carolina. It was completed in 1860 as a residential home. However, its significance is mostly due to its association with the development of the city by being used for various purposes in the past.

For example, the C.P. Quattlebaum Office became the office of the Johnson, Johnson, and Quatlebaum law firm from 1876 up to 1929. When the first bank in the city, the Bank of Conway, opened in 1893, the building was also used until 1899.

C.P. or Cephas Perry Quattlebaum was the first mayor of Conway, making the building more historically significant due to its close relationship to the man. It was listed in the National Register of Historic Places in 1986.