The Lee County Courthouse is a historic public building in Bishopville, South Carolina. Built in 1908, six years after the county was founded, it is the first and only courthouse for the county of Lee.

Costing a total of $75,000, the Lee County Courthouse was deemed as the most modern and one of the finest courthouses in all of South Carolina. it was made in the Neoclassical design, using stone and yellow bricks that suggest Roman motifs and influences. It was designed by William A. Edwards and built by the Atlanta contractor, Nicholas Ittner.

The Lee County Courthouse was listed on the National Register of Historic Places in 1981, mostly for its architectural significance and for being the only courthouse of the county of Lee, South Carolina.