Built in 1814 for the son of the local planter and merchant, John Mark Verdier I, Dr. James Robert Verdier, the house, also known as the James Robert Verdier House is a National Historic Landmark located in Beaufort, South Carolina. The structure itself is a common mansion design at the time, but it was still considered as a historic structure for its close relationship with the man who discovered the treatment for yellow fever, a disease that plagued the era and killed numerous people.

Just before the Civil War, the property was acquired by William Chisholm. This ownership led to the improvement of the Marshlands, and even made it a more stunning estate. However, during the Civil War, it was used as a headquarters by the US Sanitary Commission.