The Paul Quattlebaum House is a historic home in Conway, South Carolina. It is significant for its architecture, mostly for being a good example of a remodelled early 19th century residence. The reconstruction was done in the early 20th century, making it seem like the work was done to update the old structure to the contemporary styles.

The original construction of the Paul Quattlebaum House is not sure, but an 1890 photo shows it as a two-story gable end residence. Looking at its stylistic elements, some experts think that it was built around the early 19th century. It was remodelled in 1911 and transformed it into a Dutch Colonial revival building by Paul Quattlebaum.

The Paul Quattlebaum House was listed on the National Register of Historic Places in 1986.