We've got America's oldest continually operational Brewery in the southeastern portion of the state in Pottsville, PA.
Their black and tan is decent, porter is d@mned good, their light beer is pretty tasty and their signature beer can be ordered just about anywhere in the state by simply asking the barman for a Lager
. And if you don't like beer, well... I just feel sorry for you.
There are the Pennsylvania Wilds in Northcentral PA. In the fall, these are some of the most beautiful rolling hills (mountains for the really flat flatlanders?) in the entire state. You can see for several miles in some spots, so if you arrive at the peak time for foliage, it's a pretty impressive sight.
This is home to a large population of Amish people, aka, Menonites (sp?). It's just like stepping back in time. You'd better not be in a hurry here, because you're likely to end up behind several horse and buggy travellers (seriously). They don't use things like cars, electricity and most other modern conveniences. There are plenty of B&B style lodgings to be found, each one being unique. Really, it's one of the most unique places in the country. Well worth the visit.
. It's is one of the most historic cities in America. You can sit in the same church pew that Washington sat in while contemplating his next move during the early days of The Revolution.
You can visit Indepence Hall. It's where The Constitution was signed. Think about that. The document that governs how our government can govern us was born in this building. I don't care if you're a history buff or not, that's pretty cool. The liberty bell is just across the street too.
You can order up a cheesesteak at Pat's then walk across the street to Geno's and decide which one you prefer. Just remember you should never EVER walk across the street from one of these establishments to the other with something you bought from their rival on the other side of the street. It's not only considered poor form, but it could get you smacked around if you do this after the bars close. Consider yourself warned
(Seriously, don't do it...take a guess how I learned this...).
There's plenty more I'm sure I'm missing, but those are the highlights for me.