I've stayed at both Marriots on business, The Bohemian on West Bay and regular Marriot at the end of River St, and both are great. The Bohemian is a little pricier, by about $80 a night higher.
The Mulberry Inn on E Bay, across from River St is run by Holiday Inn, and runs around $120 or less a night, which is the best economical bet when on a family trip.
While there, check out the Chop House, great restaurant.
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