The Clemson College Sheep Barn is a building inside the Clemson University campus in Clemson, South Carolina. It was built in 1915 and is considered to be the oldest surviving agricultural structure in the university. Although an earlier dairy barn was rebuilt in the area, the sheep barn still takes the credit for being the oldest since the other was altered.

The Clemson College Sheep Barn, architecturally, is a lot like other barns. It is a rectangular building that is two stories tall. It has a brick foundation and gabled roof made with standing-seam metal. Its walls are weatherboarded and have a single door.

Listed on the National Register of Historic Places in 1990, the Clemson College Sheep Barn is a noted structure in the whole city.