Completed around the 1750s, the Prince George Winyah Episcopal Church is a historic site in Georgetown, South Carolina. It was built for the Episcopal congregation known as the Prince George Winyah which was founded in 1716. The church, as well as the congregation, is some of the oldest of their sort that are still in service in the state of South Carolina.

Named after the Prince of Wales who soon became King George II, the Prince George Winyah Church was the parish established north of the St. James Santee. First, there was a wooden church built to serve for such purpose, but soon enough, the need for a new church became apparent.

Today, the Prince George Winyah Episcopal Church continues to serve as a worship place after centuries of its completion.