Also known as the Stoney Creek Presbyterian Chapel, the Stoney Creek Independent Presbyterian Chapel of Prince William Parish is a historic religious site in Hampton County, South Carolina. It is also sometimes known as the McPhersonville Church, after the unincorporated community where it stands.

Built in 1833, the Stoney Creek Independent Presbyterian Chapel of Prince William Parish is the church of the congregation that was formed in 1785. Most of the people who went to this church are the rice planters from the Prince William Parish who also built houses on McPhersonviille to escape the mosquito infested summers in their plantations.

After the Civil War, the people continued to use the chapel, although in 1967, its membership totally diminished. Today, the Stoney Creek Independent Presbyterian Chapel of Prince William Parish is under the care of the First Presbyterian Church of Beaufort.