Fresno isn't exactly known for its vibrant culinary and craft beer scene, but there are places to be found if you look around a bit. A few of my favorites:
Sequoia Brewing company - Sequoia Brewing - Fresno's #1 MicroBrewery
Used to be the Butterfield brewery in the tower district. IMO they've steadily improved over the past several years and now have some pretty good beer to choose from. Their Buzzsaw IIPA is definitely worth a taste.
The Queen's Inn
Up in Oakhurst has a great wine and beer garden with a decent selection. The owners also run the Idle Hour Winery.