It costs about $400 to register a car for the first time in Florida, but you don't have to pay personal property taxes on it each year. Tags are issued by a county tag/tax collectors office. They don't have car safety inspections in Florida, but if you are moving to a large metropolitan area, you will most likely need to get an emissions inspection.
We just moved out of Florida, but this link might help:
Florida FAQ about Car Registration
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